What are the conclusions of the recent studies about administrating vitamin C in sepsis? The review

Introduction and purpose: Sepsis is defined by the Sepsis-3 definition as life-threatening organ dysfunction caused a dysregulated host response to infection1. Common manifestations of sepsis are fever, tachycardia, tachypnoea, confusion, hemodynamic dysfunction, worsening tissue perfusion. may cause septic shock. The immune system produces reactive oxygen species which can also have an adverse influence on vasoconstruction5. There decrease in vitamin C levels plasma patients with multiple failure6. Vitamin plays role synthesis catecholamines has antioxidant properties. usage been arousing expectations for many years.
 Brief description state knowledge: current knowledge indicates that there no beneficent effect ascorbic acid population suffered from sepsis. What more, some proof administrating be noxious factor into brain functions19. suggestions it could increase mortality8.
 Conclusions: Recent studies do not recommend treatment out question subpopulations due pathogens or failed organs would benefit. Further research this topic needs followed up.